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This means: The same dose stops working as effectively Higher doses may be required (not sustainable) Side effects or inflammatory signals may increase Cellular response plateaus or worsens Strategic cycling allows receptors to reset, restore sensitivity, and respond optimally to the peptide
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Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress
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